Name | Guanosine hydrate |
Synonyms | GR Guanosine usafcb-11 GUANOSINE D-GUANOSINE Guanine riboside GUANINE RIBOSIDE Guanosine hydrate guanosine cell culture tested 9-[BETA-D-RIBOFURANOSYL]GUANINE GUANINE-9-BETA-D-RIBOFURANOSIDE O-(BETA-D-RIBOFURANOSYL)GUANINE Guanosine Guanine 9-B-D-ribofuranoside 2-amino-9-pentofuranosyl-3,9-dihydro-6H-purin-6-one 2-Amino-9-beta-D-ribofuranosyl-9H-purine-6-(1H)-one 2-amino-9-(beta-D-xylofuranosyl)-3,9-dihydro-6H-purin-6-one 2-Amino-9-beta-D-ribofuranosyl-9H-purine-6-(1H)-one hydrate 2-amino-9-(alpha-D-xylofuranosyl)-3,9-dihydro-6H-purin-6-one |
CAS | 118-00-3 |
EINECS | 204-227-8 |
InChI | InChI=1/C10H13N5O5/c11-10-13-7-4(8(19)14-10)12-2-15(7)9-6(18)5(17)3(1-16)20-9/h2-3,5-6,9,16-18H,1H2,(H3,11,13,14,19)/t3-,5+,6-,9+/m1/s1 |
InChIKey | NYHBQMYGNKIUIF-UUOKFMHZSA-N |
Molecular Formula | C10H13N5O5 |
Molar Mass | 283.24 |
Density | 1.3790 (rough estimate) |
Melting Point | 250 °C (dec.) (lit.) |
Boling Point | 425.8°C (rough estimate) |
Specific Rotation(α) | -62 º (c=3, in 0.1 N NaOH) |
Flash Point | 423.1°C |
Water Solubility | 0.75 g/L (25 ºC) |
Solubility | Insoluble in cold water, soluble in warm water, soluble in acid and alkali, such as dilute mineral acid and hot acetic acid. Insoluble in organic solvents. Such as alcohols, ethers, chloroform and benzene. |
Vapor Presure | 2.44E-25mmHg at 25°C |
Appearance | White or white-like crystalline powder |
Color | White to light yellow |
Odor | Odorless |
Merck | 14,4566 |
BRN | 625911 |
pKa | pK1:1.9(+1);pK2:9.25(0);pK3:12.33(OH) (25°C) |
Storage Condition | room temp |
Refractive Index | -76 ° (C=1, 1mol/L N |
MDL | MFCD00010182 |
Physical and Chemical Properties | White or almost white crystalline powder. Melting point 250 °c. |
Risk Codes | 25 - Toxic if swallowed |
Safety Description | S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) S24/25 - Avoid contact with skin and eyes. S23 - Do not breathe vapour. |
UN IDs | UN 2811 6.1/PG 3 |
WGK Germany | 3 |
RTECS | MF8750000 |
FLUKA BRAND F CODES | 10-23 |
TSCA | Yes |
HS Code | 29349990 |
Hazard Note | Irritant |
Hazard Class | 6.1 |
Packing Group | Ⅲ |
Reference Show more | 1. Zhen Zixuan and Ge Shujun Determination of four nucleosides and trigonelline in Pinellia pedunculata from different habitats [J] Chinese herbal medicine 2017 v.40; No.406 (12): 85-88. 2. Liu Xueying, Zhao Yu, He Huinan, Li Xuehui, Liu Liqibin. Content determination and cluster analysis of five nucleosides in sika deer antler from different habitats [J] China Pharmacy 2018 29 (14): 1945-1949. 3. He Huinan, Tang Xiaolei, Liu Yufei, etc Content analysis of five nucleosides in sika deer antler by different processing methods [J] Shi Zhen National Medicine National Medicine 2018 29 (10): 2395-2397. 4. Liu Zhengbo, Zhang Yayu, Wang Qiuxia, etc Effect of different potassium levels on the content of nucleosides in ginseng [J] Journal of Jilin Agricultural University 2019 41 (4): 432-437. 5. Liang Jun, Wang Hengjie, Zhang Zhenling The influence of the new integrated processing technology from the origin on the alkaloids of Pinellia ternate [J] Shizhen Traditional Chinese Medicine 2017 028 (002): 357-359. 6. Sun Weijie, Wang Ming, Yang Yang, etc Quality evaluation of sika deer antler based on chemical fingerprint and multi index component content determination [J] Chinese Journal of Traditional Chinese Medicine, 2020, v.38 (03): 196-200. 7. Sun Weijie, Lv Cheng, Yang Chonghui, etc Study on the quality control of pilose antler slices based on fingerprint and multi index quantitative determination [J] Chinese herbal medicine, 2019, v.50; No.657 (22): 65-71. 8. Kong Jing, He Jing, Tan Li, Shen Lifeng, Li Qian, Zhang Yuanyuan, Lv Shan, Wu Qiuhong, Chen Mengjie, Liu Lu, Li Wenxia, Lu Dongbo, Shi Renbing, Jiang Yanyan. Research on the correlation analysis of quality characterization based on nucleosides of sunflower [J]. Journal of Beijing Chinese Medical University, 2017,40 (05): 420-427 9. Sun Weijie, Liu Li, Qi Bin, etc The application of fingerprint combined with one measurement and multiple evaluation model in the quality evaluation of pilose antler [J] Chinese Journal of Hospital Pharmacy, 2019, 039 (007): 698-703. 10. Liu Xueying, Qi Bin, Liu Yufei, et al Comparison of contents of 5 nucleosides in sika deer antler and wapiti deer antler [J] China Modern Applied Pharmacy, 2018, 035 (011): 1675-1679. 11. Li Mingbo, Duan Xiaobei, Zhang Hailin, et al Ultrasonic Extraction of Nucleoside Bases from Cicadella Flower [J] Guizhou Agricultural Science, 2014, 000 (003): 154-157. 12. Zhang Xueting, Zhong Chengzan, Yang Ming, et al Establishment of quality control method in the production process of Jinshuibao capsule [J] Chinese Journal of Experimental Formulas, 2020 (4). 13. Xiao Yunzhi, 2], Wan Lu, et al. Discussion on the analytical mode of HPLC fingerprint of turtle shell [J] Chinese Journal of Experimental Formulas, 2015, 21 (006): 32-36. 14. Dai Lili, Jin Shanxia, Fan Mengying, etc Quaternization β- Studies on Cyclodextrin Grafted Chitosan Coating for Capillary Electrophoresis Separation [J] Analysis Laboratory, 2017, 08 (v.36): 15-18. 15. Li Xuelin, Wang Kehan, Kang Huan, Shi Junhan, Wang Qingxiao, Gui Xinjing, Zhang Lu, Zhang Yao, Wang Yanli, Feng Wenhao, Zhang Pu, Yao Jing, Liu Ruixin. Comparative study of Huangbai formula granule decoction, standard decoction, and traditional decoction based on HPLC fingerprint [J]. Chinese herbal medicine, 2020,51 (01): 91-100. 16. Ma Ming, Zhang Kaixue, Xiong Chao, Wu Lan, Sun Wei, Ma Wei. Study on the quality standard of Banlangen standard decoction [J]. Chinese Journal of Traditional Chinese Medicine, 2020,35 (10): 5139-5144. 17. Wang Jue, Guo Yuxin, Yao Yi, Zhang Jian, Li Jin, Zhu Yufeng, Liu Shijia. Study on the identification of Pinellia ternate and its counterfeits based on HPLC fingerprint [J]. Journal of Nanjing University of Traditional Chinese Medicine, 2020,36 (02): 267-272. 18. Chen Jiali, Tan Mengxia, Zou Lisi, Liu Xuhong, Chen Shuyu, Shi Jingjing, Wang Chengcheng, Mei Yuqi Simultaneous determination of multicomponent components in Panax japonicus from different habitats by ultrafast liquid chromatography triple quadrupole/linear ion trap mass spectrometry [J]. Chinese Journal of Pharmacy, 2019, 54 (03): 226-233. 19. Sun Huijuan, Wang Rui, Song Qianqian, Zhou Huiyin, Fang Chengwu Determination of amino acids and nucleosides in medicine and food mint based on ultra fast liquid chromatography-mass spectrometry [J]. Food and Fermentation Industry, 2020,46 (08): 261-266. 20. Wang Pan, Chu Quangen, Xuan Yun, Cai Zhengyin. Study on HPLC-MS fingerprint of Didang Xianxiong Decoction [J]. Shizhen Traditional Chinese Medicine, 2020,31 (12): 2937-2940. 21. Lu Yushun, Wang Zeshuai, Bi Xiaodong, Xia Yunshi, Lu Si, Sun Yinshi. Establishment of the extraction method of pilose antler decoction piece extract and the application of multi-component determination in quality evaluation [J]. Chinese Herbal Medicine, 2021,52 (02): 357-366. 22. Liu Songxin, Gong Ruize, Wang Zeshuai, Zhang Lei, Liu Chang, Lu Yushun, Sun Yinshi. Comparative study on 9 kinds of chemical components of Antler Antler Antler and Cervus Velvet Antler based on principal component analysis and discriminant analysis [J]. Chinese herbal medicine,2021,52(01):82-90. 23. Meichen Liu, Yunxia Li, Yunqiu Tang, Li Zheng, Cheng Peng, Synergistic effect of Aconiti Lateralis Radix Praeparata water-soluble alkaloids and Ginseng Radix et Rhizoma total ginsenosides compatibility on acute heart failure rats, Journal of Chromatography 24. Xia, Yuanyuan, et al. "Characterization, quantitation and similarity evaluation of Codonopsis lanceolata from different regions in China by HPLC-Q-TQF-MS and chemometrics." Journal of Food Composition and Analysis 62 (2017): 134-142.https://doi.org/10.1016 25. Qin Hu, Lu Gao, Sheng-qi Rao, Zhen-quan Yang, Tao Li, Xiaojuan Gong, Nitrogen and chlorine dual-doped carbon nanodots for determination of curcumin in food matrix via inner filter effect, Food Chemistry, Volume 280, 2019, Pages 195-202, ISSN 0308-8146, htt 26. Wen Jie Zhang, Shi Gang Liu, Lei Han, Hong Qun Luo, Nian Bing Li,A ratiometric fluorescent and colorimetric dual-signal sensing platform based on N-doped carbon dots for selective and sensitive detection of copper(II) and pyrophosphate ion,Sensors and Ac 27. Wang, Chengcheng, et al. "Distribution patterns for metabolites in medicinal parts of wild and cultivated licorice." Journal of pharmaceutical and biomedical analysis 161 (2018): 464-473.https://doi.org/10.1016/j.jpba.2018.09.004 28. [IF=7.514] Qin Hu et al."Nitrogen and chlorine dual-doped carbon nanodots for determination of curcumin in food matrix via inner filter effect."Food Chem. 2019 May;280:195 29. [IF=7.46] Wen Jie Zhang et al."A ratiometric fluorescent and colorimetric dual-signal sensing platform based on N-doped carbon dots for selective and sensitive detection of copper(II) and pyrophosphate ion."Sensor Actuat B-Chem. 2019 Mar;283:215 30. [IF=5.923] Cuihua Chen et al."Variations in Physiology and Multiple Bioactive Constituents under Salt Stress Provide Insight into the Quality Evaluation of Apocyni Veneti Folium."Int J Mol Sci. 2018 Oct;19(10):3042 31. [IF=4.556] Yuanyuan Xia et al."Characterization, quantitation and similarity evaluation of Codonopsis lanceolata from different regions in China by HPLC-Q-TQF-MS and chemometrics."J Food Compos Anal. 2017 Sep;62:134 32. [IF=4.411] Cuihua Chen et al."Quality Evaluation of Apocyni Veneti Folium from Different Habitats and Commercial Herbs Based on Simultaneous Determination of Multiple Bioactive Constituents Combined with Multivariate Statistical Analysis."Molecules. 2018 Mar;23(3):5 33. [IF=4.411] Yujiao Hua et al."Quality Evaluation of Pseudostellariae Radix Based on Simultaneous Determination of Multiple Bioactive Components Combined with Grey Relational Analysis."Molecules. 2017 Jan;22(1):13 34. [IF=2.896] Ya-yun Chen et al."Determination of free amino acids and nucleosides and nucleobases in Annona squamosa L. fruitages from different regions in China by LC-QTRAP-MS/MS."Anal Methods-Uk. 2017 Jun;9(25):3862-3869 35. [IF=1.618] Li Yan et al."Simultaneous Determination and Comparative Pharmacokinetics of Fuzi Water-Soluble Alkaloids between Normal and Acute Heart Failure Rats by Ultra Performance Liquid Chromatography Method."J Chromatogr Sci. 2017 Aug;55(7):719-728 36. [IF=6.986] Yu-Fang Ma et al."Synthesis of a pH-Responsive Functional Covalent Organic Framework via Facile and Rapid One-Step Postsynthetic Modification and Its Application in Highly Efficient N1-Methyladenosine Extraction."Anal Chem. 2020;92(1):1424–1430 37. [IF=4.411] Mengxia Tan et al."Quality Evaluation of Ophiopogonis Radix from Two Different Producing Areas."Molecules. 2019 Jan;24(18):3220 38. [IF=4.411] Shengxin Yin et al."Comparison of Multiple Bioactive Constituents in the Corolla and Other Parts of Abelmoschus manihot."Molecules. 2021 Jan;26(7):1864 39. [IF=4.27] Cuihua Chen et al."Metabolomics characterizes metabolic changes of Apocyni Veneti Folium in response to salt stress."Plant Physiol Bioch. 2019 Nov;144:187 40. [IF=4.142] Wang Chenxi et al."Systematic quality evaluation of Peiyuan Tongnao capsule by offline two-dimensional liquid chromatography/quadrupole-Orbitrap mass spectrometry and adjusted parallel reaction monitoring of quality markers."Anal Bioanal Chem. 2019 Nov;4 41. [IF=3.004] Meichen Liu et al."Synergistic effect of Aconiti Lateralis Radix Praeparata water-soluble alkaloids and Ginseng Radix et Rhizoma total ginsenosides compatibility on acute heart failure rats."J Chromatogr B. 2020 Jan;1137:121935 42. [IF=1.618] Wang Shengnan et al."Simultaneous Determination of Iridoid Glycosides, Phenylpropanoid Glycosides, Organic Acids, Nucleosides and Amino Acids in Scrophulariae Radix Processed by Different Processing Methods by HPLC-QTRAP-MS/MS."J Chromatogr Sci. 2021 Jun; 43. [IF=6.529] Yarigui Bao et al."Therapeutic effects of Chinese medicine Di-Long (Pheretima vulgaris) on rheumatoid arthritis through inhibiting NF-κB activation and regulating Th1/Th2 balance."Biomed Pharmacother. 2022 Mar;147:112643 44. [IF=4.411] Nan Wu et al."Quality Evaluation of Taxilli Herba from Different Hosts Based on Simultaneous Determination of Multiple Bioactive Constituents Combined with Multivariate Statistical Analysis."Molecules. 2021 Jan;26(24):7490 |